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Pityriasis lichenoides chronica histology

Pityriasis Lichenoides: A Large Histopathological Case

Introduction: Pityriasis lichenoides (PL) is an infrequent skin disorder. The clinical manifestations are usually specific enough for a reliable diagnosis, although the histopathological assessment of a biopsy is sometimes needed to differentiate between PL and a range of other diseases Pityriasis lichenoides chronica was diagnosed in 39 cases (76.47%) and pityriasis lichenoides et varioliformis acuta (PLEVA) in 12 cases (23.53%). Histopathologically, basal cell vacuolation and perivascular infiltrate were seen in all the cases. Exocytosis was seen in 45.1% of the cases Pityriasis lichenoides chronica (PLC) is a skin disease that causes the development of small, scaling, raised spots (papules) on the skin. PLC is the relatively mild form of the disease pityriasis lichenoides Pityriasis lichenoides is an uncommon rash of unknown cause. It can range from a relatively mild chronic form to a more severe acute eruption. The mild chronic form, pityriasis lichenoides chronica (PLC), is characterised by the gradual development of symptomless, small, scaling papules that spontaneously flatten and regress over weeks

Histology Superficial lymphocytic infiltrate, slight exocytosis, sometimes slight spongiosis, parakeratosis, slight vacuolar degeneration of the basal layer The signs and symptoms of pityriasis lichenoides chronica (PLC) include the development of papules on the skin. The papules typically begin as small, firm, pink spots, and they may have a scaly layer on the top. Over time, the papules typically turn brown in color and eventually fade. This process may occur over a few weeks Rare, harmless, probably infection-triggered (viral triggers?), erythematosquamous, self-limited chronic dermatitis classified as a chronic course form of pityriasis lichenoides. The disease may arise de novo or evolve from the acute course of pityriasis lichenoides (et varioliformis) acuta Pityriasis lichenoides is an uncommon disease of the skin that can present in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulceronecrotic Mucha-Habermann disease (FUMHD). These three forms represent a spectrum of disease presentation Localized acral pityriasis lichenoides chronica: report of a case. Halbesleben JJ, Swick BL. PMID: 21352323. [PubMed - indexed for MEDLINE

Background Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin that classically present as either a recurrent papulonecrotic eruption (PLEVA) or a persistent, scaling, papular eruption (PLC). Observations of both types of lesions present on individual patients have led to speculation that both entities. Pityriasis Lichenoides 6 Tips That Help Me Manage My Chronic Skin Condition As a published author, I thought my third book might center around living with PLC (or pityriasis lichenoides chronica) — a diagnosis I received in my teens and have lived with ever since BACKGROUND: Pityriasis lichenoides chronica (PLC) and pityriasis lichenoides et varioliformis acuta (PLEVA) are benign T-cell diseases that share several overlapping clinicopathologic features, leading many to believe that they exist as a spectrum rather than as single entities The histopathology of MCTD mimics SCLE by virtue of the lymphocytic interface dermatitis, but it differs by showing vasculopathic alterations comprising ectasia, hypovascularity, and luminal thrombosis confined to the superficial vascular plexus, and sometimes by a concomitant sclerodermoid tissue reaction. 21 As mentioned, distinction from dermatomyositis can be problematic

Pityriasis lichenoides is a dermatologic diagnosis consisting of three main forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulceronecrotic Mucha-Habermann disease (FUMHD). Histologically, PLEVA is characterized by focal changes to the epidermis and dermis The histopathology of pityriasis lichenoides chronica reveals a superficial CD4+ T-dominant lymphocytic, band-like, sparsely perivascular infiltrate. It also exhibits slight parakeratotic scale and minimal keratocytic necrosis and spongiosis in the epidermis Pityriasis lichenoides chronica (PLC) is rarely as symptomatic as it is alarming. When this form of parapsoriasis was being described in the literature it was grouped under the rhythmic eruptions due to the unexplainable eruption of multiple lesions followed by the gradual involution and fading of that crop Keratosis lichenoides chronica is characterised by brownish-purple, thick scaly papules or small nodules on the trunk and extremities. The papules are generally arranged in a linear or reticular pattern and are symmetrically distributed. They are usually asymptomatic but can be itchy in 20% of cases

Pityriasis lichenoides represents a group of uncommon skin disorders that tend to affect children and young adults, and are divided into two main conditions: pityriasis lichenoides chronica (PLC) and pityriasis lichenoides et varioliformis acuta (PLEVA) INTRODUCTION. Pityriasis lichenoides is a term used to refer to a group of rare acquired inflammatory skin disorders that includes pityriasis lichenoides chronica (PLC), pityriasis lichenoides et varioliformis acuta (PLEVA), and the febrile ulceronecrotic Mucha-Habermann disease (FUMHD) variant of PLEVA Pityriaisis Lichenoides Chronica - can you say that again? Pretty sure this was what I said when I first learned about this lesion.Pityriasis- Hippocrates. We retrospectively identified 97 examples of interface dermatitis with clinically confirmed diagnoses, including lupus erythematosus (LE), lichen planus, pityriasis lichenoides (PL), graft‐vs.‐host disease (GVHD), dermatomyositis (DM) and drug reaction. Diagnoses were clinically confirmed by at least two dermatologists Panizzon RG, Speich R, Dazzi H. Atypical manifestations of pityriasis lichenoides chronica: development into paraneoplasia and non-Hodgkin lymphomas of the skin. Dermatology. 1992. 184(1):65-9. . Geller L, Antonov NK, Lauren CT, Morel KD, Garzon MC. Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options

Video: A clinical and histopathological study of pityriasis

Pityriasis lichenoides chronica Jeffrey S Henning DO Dermatology Online Journal 10 (3): 8 From the Ronald O. Perelman Department of Dermatology, New York University Abstract. A 19-year-old woman presented with a five-year history of guttate macules and yellow to skin-colored papules with collarette of fine scale on the trunk and the upper and lower extremities Pityriasis lichenoides is a rare cutaneous disorder of unknown etiology. Pityriasis lichenoides encompasses a spectrum of clinical presentations ranging from acute papular lesions that rapidly evolve into pseudovesicles and central necrosis (pityriasis lichenoides et varioliformis acuta or PLEVA) to small, scaling, benign-appearing papules (pityriasis lichenoides chronica or PLC) • Eleven patients with chronic pityriasis lichenoides chronica were treated with topically applied bland emollient cream and minimally erthemogenic doses of UV radiation from fluorescent sunlamps. The conditions of all patients cleared completely in an average of 29 treatments, requiring an average UV dose of 388 millijoules/sq cm at clearance Pityriasis lichenoides is a dermatologic diagnosis consisting of three main forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulceronecrotic Mucha-Habermann disease (FUMHD). Histologically, PLEVA is characterized by focal changes to the epidermis and dermis . A vacuolar interface. David Weedon AO MD FRCPA FCAP(HON), in Weedon's Skin Pathology (Third Edition), 2010. PITYRIASIS LICHENOIDES. In the acute form of pityriasis lichenoides, pityriasis lichenoides et varioliformis acuta (PLEVA), there is a heavy lymphocytic infiltrate which obscures the dermoepidermal interface in much the same way as it does in erythema multiforme and fixed drug eruption (Fig. 3.34)

Pityriasis lichenoides chronica Genetic and Rare

  1. Pityriasis lichenoides (PL) has traditionally been classified as a benign papulosquamous disease. However, there is an increasing literature precedent that suggests that PL should instead be considered a form of cutaneous lymphoid dyscrasia
  2. Pityriasis lichenoides chronica (PLC), which is a benign eruption with lymphocytic infiltrates of the skin, presents as apersis - tent, erythematous, papular eruption with scale. Patients may have gut - tate, hypopigmented macules with scale in addition to papules. It is re-lated histopathologically to pityriasis lichenoides et varioliformis acut
  3. Pityriasis lichenoides chronica (PLC) is a benign, self-limited, diffuse skin eruption composed of discrete red-brown scaly papules ().In darker-skinned patients, PLC may present instead with hypopigmented nonscaly macules and patches (). 1 Individual lesions typically last from weeks to several months, whereas the eruption persists from months to years in a given patient

on the skin of the trunk and the extremities. Possibility for pityriasis lichenoides chronica, parapsoriasis small plaque form or lichen planus was considered. A skin biopsy was taken, and histological examination revealed evidence for pityriasis lichenoides chronica. Due to the suspicion for drug induced pityriasis, acetylsalicylic aci Coming to terms with Louis Brocq and his diagram: Pityriasis lichenoides 2018. A and B, Pityriasis lichenoides chronica-like drug eruption. The lower legs show several, 3- to 4-mm, red-brown, thin papules with centrally adherent micaceous scale and intermixed erosions. As a first-year dermatology resident in 1980, I struggled with the concept.

Pityriasis lichenoides DermNet N

Segmental pityriasis lichenoides chronica. S. Cliff. Department of Dermatology, St George's Hospital, London SW17 OQT, UK. Search for more papers by this author. M.G. Cook. Department of Pathology, St George's Hospital, London SW17 OQT, UK. Search for more papers by this author. L.S. Ostloere Pityriasis lichenoides chronica (PLC) is a subacute or chronic disorder characterized by small, scaly, red-brown maculopapules (as reviewed by Fernandes et al 55). The distinction between PLEVA and PLC is not always clear-cut, and a continuum of findings with some degree of overlap is often observed Wprowadzenie. pityriasis lichenoides chronica (PLC), która jest łagodną osutką z obecnością nacieków limfocytarnych w skórze, manifestuje się jako długo utrzymujące się rumieniowo-grudkowe wykwity z obecnym złuszczaniem. Oprócz grudek można stwierdzić odbarwione,.. Mucha-Habermann disease, also known as pityriasis lichenoides et varioliformis acuta or PLEVA, is a rare skin disorder. The lesions most often appear on the trunk and the arms and legs. Lesions tend to develop in small groups. Mucha-Habermann disease most often affects children or young adults. A more severe variant of this disorder, known as.

Introduction . Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology. Case Report . A 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules located predominantly in trunk in each recurrence. Positive serologies to herpes simplex virus type 2 were detected Pityriasis lichenoides chronica: stratification by molecular and phenotypic profile. Academic Article Overview abstract . Pityriasis lichenoides (PL) has traditionally been classified as a benign papulosquamous disease. However, there is an increasing literature precedent that suggests that PL should instead be considered a form of cutaneous. pityriasis lichenoides chronica (PLC). Pityriasis lichenoides et varioliformis acuta, the acute variant, is characterized by the onset of papulovesicular eruptions that evolve into necrotic lesions over the trunk and extremities, and hence the name varioliformis, which means like variola (like smallpox). Pityriasis lichenoides. Erythemato-squamous, acute or chronic, self-limiting skin disease of unexplained etiology and pathogenesis, which was classified by the work of Brocq (1902) as a parapsoriasis disease, i.e. a psoriasis-like disease.(Note: this classification can no longer be maintained) The different clinical manifestations of pityriasis lichenoides are considered as variants of the same clinical picture with. Kim JE et al. Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica: comparison of lesional T-cell subsets and investigation of viral associations. J Cutan Pathol. 2011;38:649-56. PubMed Article Google Scholar 8. Bowers S, Warshaw EM. Pityriasis lichenoides and its subtypes

Pityriasis lichenoides chronica (PLC) PLC usually presents with small pink papules that turn a reddish-brown colour. It resembles pityriasis rosea. The eruption is often polymorphic, with lesions at different stages of development. PLC is usually distributed over the trunk, buttocks and proximal arms or legs Pityriasis lichenoides et varioliformis acuta •Abrupt onset of multiple papules on trunk, buttocks, proximal extremities •Rapidly progress to vesicles & hemorrhagic crusts •Minor constitutional symptoms fever, malaise & myalgias Pityriasis lichenoides chronica • May develop over days • Same distributio This is a challenging disorder to diagnose, categorise, and treat due to its varied presentation and uncertain course. The integral diagnostic test for pityriasis lichenoides is histology. Histology can also delineate different subtypes of pityriasis lichenoides. Bowers S, Warshaw EM. Pityriasis lichenoides and its subtypes Pityriasis lichenoides (PL) is an uncommon, acquired spectrum of skin conditions that poses various challenges to patients as well as clinicians. It is a difficult and debatable disorder to diagnose, categorize, and treat. Besides these inherent obstacles, PL merits awareness because of its potential to progress to cutaneous lymphoma or an ulceronecrotic presentation, both of which carry a.

Pityriasis lichenoides chronica Red-brown papules with central mica-like scales randomly arranged on trunk and proximal extremities with chronic, relapsing course; hypo- or hyperpigmentation may. Pityriasis lichenoides chronica presenting as hypopigmentation. Br J Dermatol. 1979; 100(3):297-302 (ISSN: 0007-0963) Clayton R; Warin A. Seven black or dark skinned patients with pityriasis lichenoides chronica (PLC) are described, who presented with widespread hypopigmentation

Pityriasis lichenoides (acuta and chronica) Pityriasis lichenoides variants describe scaly dermatoses with necrotic papules that are clinically and histologically different from parapsoriasis Pityriasis lichenoides chronica (PLC) is a rare inflammatory skin disorder of unknown etiology that is considered as a subtype of pityriasis lichenoides. Patients with PLC usually present with widely distributed red-brown papules on the trunk and extremities. Pathology image of epidermis with parakeratosis and mild acanthosis and papillary. Pityriasis lichenoides (PLs) is an uncommon skin disease of unknown etiology. In recent years, an atypical form of PL has been described, showing overlapping features with mycosis fungoides (MF) and lymphomatoid papulosis.We studied 66 patients with an initial histopathologic diagnosis of PL (M:F=34:32; median age, 25 y; range, 7 to 85 y) Hypochromic variant of pityriasis lichenoides chronica Hypochromic variant of pityriasis lichenoides chronica WARIN, A.P. 1978-03-01 00:00:00 A.P.WARIN St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Accepted for publication 15 August 1977 Case I History Miss A. (St John's Hospital no. P71678) a 26-year-old woman from Ghana, had a 2 year history of.

Atlas of dermatopathology: Pityriasis lichenoides chronic

Pityriasis lichenoides Genetic and Rare Diseases

Picture of Pityriasis Lichenoides

Pityriasis lichenoides chronica - Altmeyers Encyclopedia

Clinical features of pityriasis lichenoides et

Pityriasis Lichenoides - American Osteopathic College of

Pityriasis lichenoides chronicaelike drug eruption developing during pembrolizumab treatment for metastatic melanoma KrishnaA.J.Mutgi,MD,a Mohammed Milhem, MD,b BrianL.Swick,MD,a,c and Vincent Liu, MDa,c Iowa City, Iowa Key words: pembrolizumab; pityriasis lichenoides chronica; programmed death receptor 1. INTRODUCTIO Lichen planus pigmentosus- LPPg Recently described entities that manifest a Pityriasis lichenoides chronica- PLC lymphocytic interface inflammatory infiltrate include HIV-related dermatoses, cutaneous T-cell dyscrasias, mycosis Lichen striatus- LS fungoides, and autoimmune thyroiditis.[5] Confirmed histology 75 83.33% Diagnosed on histology. Pityriasis Rosea: Histology • Non-specific subacute dermatitis • Focal hyperkeratosis pityriasis lichenoides, glucagonoma, deficiency states, granular parakeratosis - Pityriasis lichenoides chronica (PLC) Pityriasis Lichenoides • M:F ratio 3: pityriasis lichenoides chronica pityriasis lichenoides et varioliformis acuta poikiloderma atrophicans vasculare skin graft rejection subacute cutaneous lupus erythematosus. Examples. cutaneous syphilis / secondary syphilis: psoriasiform pattern + lichenoid infiltrate with histiocytes great clue. Plasma cells + Below is a list of common natural remedies used to treat or reduce the symptoms of Pityriasis+Lichenoides+Chronica+ (Plc). Follow the links to read common uses, side effects, dosage details and.

Localized acral pityriasis lichenoides chronica: report of

Histology in Favor of Lupus DD Fixed Drug Eruption vs Pathomimie. Hodgkin's Lymphoma. Read more. Hodgkin's Lymphoma. Hydroa Vacciniforme. Read more. Pityriasis Lichenoides Chronica (PLC) Pityriasis Rosé de Gibert. Read more. Pityriasis Rosé de Gibert. Pityriasis Rosea. Read more. Pityriasis Rosea. Pityriasis Rubra Pilaris Meshell Powell Someone with pityriasis lichenoides chronica should take special precaution to avoid a sunburn. Pityriasis lichenoides chronica is a rare skin condition that causes small raised papules to develop on various areas of the skin. The exact cause of this disorder is not clearly understood, although there are a number of theories surrounding the origin of this rash

Background: Pityriasis lichenoides (PL) is a lymphoproliferative disease of unknown origin; its diagnosis is based on clinical characteristics and confirmed by histology. Objectives: To describe clinical and histological features of PL in 29 pediatric patients. Materials and Methods: Retrospective descriptive study of children (patients less than 15 years old) diagnosed with PL between 1986. Pityriasis lichenoides chronica (PLC) is a rare skin disease of uncertain aetiology. Many infectious agents have been incriminated as the cause of the disease. One of these agents is toxoplasmosis. The aim of this work was to find out if there is a relationship between toxoplasmosis and PLC each genital herpes recurrence. In conclusion, we report a case in which cutaneous lesions of pityriasis lichenoides chronica and a herpes simplex virus-type 2-mediated disease have evolved concomitantly. 1.Introduction Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology, although infectiou Pityriasis amiantacea is an eczematous condition of the scalp in which thick tenaciously adherent scale infiltrates and surrounds the base of a group of scalp hairs. It does not result in scarring or alopecia.: 647 Pityriasis amiantacea was first described by Alibert in 1832. Pityriasis amiantacea affects the scalp as shiny asbestos-like (amiantaceus) thick scales attached in layers to the.

Malignant Transformation of Pityriasis Lichenoides chronica Infection Viral: CMV, EBV, HSV, VZV Bacterial: TB, atypical mycobacterium, Gonoccacaemia, Syphilis . Investigations Baseline Bloods Hb 10.8, MCV 98 ALT 130, ALP 418, Bili 5 WCC 9.8 Microbiology Negative Blood cultures, Wound culture Pityriasis lichenoides et varioliformis acuta (PLEVA, ziekte van Mucha-Habermann) en pityriasis lichenoides chronica (PLC, parapsoriasis guttata, parapsoriasis en goutes) worden beschouwd als twee verschillende uitingen van hetzelfde ziektebeeld.PLEVA en PLC worden ook wel ingedeeld in de parapsoriasis groep: Parapsoriasis - pityriasis lichenoides chronica The diagnosis of pityriasis rosea is based on clin - ical and physical examination findings. Classic pityriasis rosea starts with a herald patch on the trunk (Figures 1 and 21) in up to 90% of cases.

Video: The Clonal Nature of Pityriasis Lichenoides Dermatology

Abstract: Pityriasis lichenoides comprises a clinicopathological spectrum of cutaneous inflammatory disorders, with the two most common variants, pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica. The aim of the study is to describe 13 cases of a unique PLEVA variant characterized with a conspicuou Pityriasis Lichenoides Add Pityriasis Lichenoides Chronica Add Pityriasis Lichenoides et Varioliformis Acuta Add Pityriasis Lichenoides, Acute Add Pityriasis Lichenoides, Chronic Add Pharm Action Registry Number CAS Type 1 Name NLM Classification # Previous Indexing Parapsoriasis (1966-1985) Pityriasis (1977-1992 Pityriasis lichenoides chronica is similar to these medical conditions: Confluent and reticulated papillomatosis, Post-vaccination follicular eruption, Alphavirus infection and more Pityriasis lichenoides chronica usually resolves on its own. As an accompanying measure—or when complications arise—carefully dosed ultraviolet B phototherapy and corticosteroids may be used. Pityriasis rubra pilaris. Definition, etiology, and epidemiology. Pityriasis Rubra Pilaris (PRP) is a type of papulosquamous skin condition

6 Tips for Managing Pityriasis Lichenoides Chronica The

Pityriasis Lichenoides Chronica | Basicmedical Key

Differentiation and clonality of lesional lymphocytes in

Background: Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with. Pityriasis lichenoides et varioliformis acuta (PLEVA) is an eruption of small, erythematous papules which become vesicular and hemorrhagic. Some ulcerate and necrose, leaving pitted scars. The name refers to the morphology not the duration of the condition, because a significant proportion of cases regress with or without treatment, only to recur

Parapsoriasis and Pityriasis Lichenoides | Plastic Surgery KeyKeratosis Lichenoides Chronica (Nekam disease, lichen

Interface Dermatitis Archives of Pathology & Laboratory

Lichen nitidus is a chronic inflammatory disease of unknown cause characterized by 1-2 mm, discrete and uniform, shiny, flat-topped, pale flesh-colored or reddish-brown papules that may appear as hypopigmented against dark skin. Occasionally, minimal scaling is present or can be induced by rubbing the surface of the papules. The disease usually affects children and young adults and is. Define pityriasis lichenoides et varioliformis, acuta. pityriasis lichenoides et varioliformis, acuta synonyms, pityriasis lichenoides et varioliformis, acuta pronunciation, pityriasis lichenoides et varioliformis, acuta translation, English dictionary definition of pityriasis lichenoides et varioliformis, acuta Pityriasis lichenoides et varioliformis acuta (PLEVA). There is a superficial and deep perivascular lymphocytic infiltrate that obscures dermoepidermal junction (A). Neutrophils are in stratum corneum admixed with degenerated necrotic keratinocytes and parakeratotic corneocytes (B) Pituitary Function Tests is a.k.a Mucha-Habermann disease. Pityriasis lichenoides is a rare skin disorder of unknown aetiology. More about Pityriasis Lichenoides

Pityriasis Lichenoides Chronica in a Patient With

Cureus Clinical, Dermatoscopic, and Histological

191. Pityriasis lichenoides chronica. 192. Pityriasis Lichenoides et varioliformis acuta. 193. Pityriasis rosea. 194. Polycystic ovary syndrome . 195. Polymorphic light eruption. 196. Porokeratoses. 197. Porphyria cutanea tarda. 198. Port wine stain (nevus flammeus) 199. Postinflammatory hyperpigmentation and other disorders of. Pityriasis lichenoides et varioliformis acuta (also known as acute guttate parapsoriasis, acute parapsoriasis, acute pityriasis lichenoides, Mucha-Habermann disease, parapsoriasis acuta, parapsoriasis lichenoides et varioliformis acuta, and parapsoriasis varioliformis) is a disease of the immune system.It is the more severe version of pityriasis. The clinical differential diagnosis on most pathology requisition forms for this presentation includes any number of the following four disorders: guttate psoriasis . pityriasis rosea (PR) pityriasis lichenoides chronica (PLC), and. secondary syphilis. Clinical Clues 2 variants of pityriasis lichenoides. chronica and pityriasis lichenoides et varioliformis acuta. T or F: clonality = malignancy. false, clonality seen in many dermatoses. Size of most large plaque parapsoriasis lesions? small plaque parasporiasis? LPP >5cm often >10cm diameter Answer: Pityriasis lichenoides chronica. See the full case at Consultant360. A biopsy supported the diagnosis of pityriasis lichenoides chronica (PLC), a rare and poorly understood condition that manifests as a benign eruption with lymphocytic infiltrates of the skin

Pityriasis lichenoides chronica - wikidocResolution of pityriasis lichenoides chronica after narrow

In our case, the patient's pityriasis lichenoides chronica-like drug eruption rapidly improved with high potency topical steroids, allowing continuation of pembrolizumab therapy. Subsequent development of inflammatory arthritis, however, necessitated discontinuation of pembrolizumab and initiation of methotrexate therapy Acute conditions may become longstanding and move into its chronic form (Pityriasis Lichenoides Chronica) The longstanding lesions can cause self-image issues, emotional stress, and psychological trauma in some individuals, leading to depression Journal of cutaneous pathology, 31(8), 531-538 Immune checkpoint inhibitors such as ipilimumab (anticytotoxic T-lymphocyte-associated antigen), pembrolizumab, and nivolumab (anti-programmed death receptor 1) represent some of the newest and most promising medications for the treatment of metastatic melanoma.1 As a class, immune checkpoint inhibitors interfere with tumoral suppression of T cells, resulting in a more robust immune. The Mucha-Habermann disease is an inflammatory disease of the skin and is a variant of pityriasis lichenoides et varioliformis acuta. We describe the case of a 64-years-old woman who was admitted for erysipelas of the face. Despite treatment, evolution was marked by the appearance of a necrotising ulcerative area in the centre of the erysipelas associated with local oedema and headache