For injection: Single-dose vial containing 500 mg of ganciclovir as a sterile lyophilized white to off-white powder for reconstitution with 10 mL of preservative-free sterile water for injection, USP for intravenous use. The concentration of ganciclovir in the reconstituted solution is 50 mg/mL [see Dosage and Administration (2.6) ] Ganciclovir is an anti-viral drug. It is used to prevent disease caused by a virus called cytomegalovirus (CMV) in people who have received organ or bone marrow transplants GANCICLOVIR INJECTION is a nucleoside analogue CMV DNA polymerase inhibitor indicated for the: Treatment of CMV retinitis in immunocompromised adult patients, including patients with acquired..
CYTOVENE®-IV (ganciclovir sodium for injection) is supplied in 10 mL sterile vials, each containing ganciclovir sodium equivalent to 500 mg of ganciclovir, in cartons of 25 (NDC 0004-6940-03) Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis. Indication. Intermittent Hemodialysis. Continuous Hemodialysis. CMV Induction. 1.25 mg/kg IV x1 now and post-HD. 2.5-5 mg/kg IV q12-24h. CMV Maintenance. 0.625 mg/kg IV x1 now and post-HD
-IV ganciclovir therapy should be reserved for infants with symptomatic congenital CMV disease; therapy is not appropriate for infants with asymptomatic congenital CMV infection IV Ganciclovir 4. IV Acyclovir 5. Liposomal Amphotericin B 6. IV Trimethoprim-sulfamethoxazole 7. Foscarnet 8. Colistin (maximum 300 mg total daily dose) 9. Polymyxin B (maximum 200 mg total daily dose) 10. Ribavirin 11. Cidofovir BMI is automatically calculated in MiChart (Flowsheets tab-> Height/Weight). BMI can also be calculated using the. . Each 10 mL clear glass vial contains ganciclovir sodium equivalent to 500 mg of ganciclovir. Wearing disposable gloves is recommended during reconstitution and whe
Cytovene IV; Descriptions. Ganciclovir is an antiviral. It is used to treat infections caused by viruses. Ganciclovir is used to treat the symptoms of cytomegalovirus (CMV) infection of the eyes in people whose immune system is not working fully. This includes patients with acquired immune deficiency syndrome (AIDS) Ganciclovir capsules are used to treat CMV retinitis after the condition has been controlled by intravenous (injected into a vein) ganciclovir. Ganciclovir is also used to prevent cytomegalovirus (CMV) disease in people who have acquired immunodeficiency syndrome (AIDS) or who have received an organ transplant and are at risk of CMV disease For treatment of CMV retinitis after you have received ganciclovir injection for at least fourteen to twenty-one days: Adults and teenagers—1000 milligrams (mg) three times a day with food; or 500 mg six times a day, every three hours with food, during waking hours. Children—Use and dose must be determined by your doctor Ganciclovir is a synthetic analogue of 2′-deoxy-guanosine.It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV.
The recommended initial dosage of CYTOVENE-IV solution for patients with normal renal function is 5 mg/kg (given intravenously at a constant rate over 1 hour) every 12 hours for 7 to 14 days, followed by 5 mg/kg once daily, 7 days per week or 6 mg/kg once daily, 5 days per week. The duration of treatment with CYTOVENE-IV solution in transplant. Intravenous ganciclovir is the standard treatment for cytomegalovirus disease in solid organ transplant recipients. Oral valganciclovir is a more convenient alternative
Ganciclovir is an antiviral medicine used to treat CMV retinitis in people with immunosuppression caused by HIV or AIDS. Ganciclovir is also used to prevent CMV disease in people with.. The pharmacokinetics and effect of hemodialysis on the clearance of ganciclovir were evaluated in a patient with cytomegalovirus (CMV) retinitis and pneumonitis requiring dialytic support. A dose of 300 mg ganciclovir (5 mg/kg) was administered by intravenous infusion over a 60-minute period. Blood Ganciclovir must be administered by intravenous infusion over 1 hour at a concentration not exceeding 10 mg/mL. Do not administer by rapid or bolus intravenous injection because the resulting excessive plasma levels may increase the toxicity of ganciclovir Ganciclovir (also called Cytovene ®) is a medicine used to prevent or treat infections caused by cytomegalovirus (also called CMV). It is available as a clear liquid given into a vein (IV). Ganciclovir can pose a health hazard to caregivers. All caregivers should take safety precautions while giving this drug Ganciclovir is a nucleoside analogue and antiviral agent used in therapy of cytomegalovirus infections. Valganciclovir is the valyl ester prodrug of ganciclovir which can be given orally. When given intravenously, ganciclovir can cause mild, transient and asymptomatic elevations in serum aminotransferase levels, but neither ganciclovir nor valganciclovir have been associated with clinically.
. Ganciclovir may cause temporary or permanent sterility or infertility in both men and women. Birth defects have occurred in animals, therefore is NOT recommended during pregnancy, and men and women should use barrier contraception (ie: condoms) during and for 90 days following treatment. It is not know For CMV treatment, the standard dosing of ganciclovir is 900 mg every 12 hours for oral valganciclovir and 5 mg/kg every 12 hours for IV ganciclovir. 3 In case of renal impairment and dialysis, dosages should be adjusted according to renal function to avoid serious side effects such as neutropenia and myelosuppression. 4-7 Ganciclovir has a.
For neonatal HSV, intravenous ganciclovir should be used at the dose of 6 mg/kg/dose IV every 12 hours, which is the dose studied by the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group for treatment of symptomatic congenital cytomegalovirus disease Ganciclovir, in both i.v. and oral formulations, is commonly used to prevent and to treat CMV infection, although the optimal dose and duration of therapy have not yet been completely defined . In clinical practice, patients requiring prophylaxis or treatment for CMV infection often have abnormal or fluctuating renal function During these trials, CYTOVENE-IV or ganciclovir capsules were prematurely discontinued in 9% of subjects because of adverse reactions. Selected adverse reactions and laboratory abnormalities reported during the conduct of these controlled trials are summarized in Table 2 and Table 3, respectively [see Clinical Studies ]
C max is 40% lower than IV ganciclovir Significant bone deposition may occur in young patients Hemodialysis may reduce plasma levels When administered with probenecid, 70%-85% of drug is excreted unchanged in 24 h High flux hemodialysis reduces plasma levels by ∼75% Jan 12, 2011. From what I found, it says if you come in skin contact with the broken or crushed ganciclovir capsules, just wash the affected area well with soap and water. I assume the same applies to the iv form. I don't think you have anything else to worry about, especially just a few drops. 0 Likes Ganciclovir Irritant Yes Yes Yes Gentamicin Irritant Yes Yes Yes Metronidazole Irritant Yes Yes Yes Nafcillin Irritant Monitor No (if A) Yes For continuous infusions, central Penicillin Irritant Yes No (if A) Yes administration is preferred. Pentamidine Irritant Yes Yes Yes. For first 5 days, dosing of intravenous ganciclovir is 10 mg/kg daily, given as 5 mg/kg every 12 hours (adjusted for renal function). After first 5 days (up to 28 days) IV ganciclovir 5 mg/kg QD ( adjusted for renal function). A minimum interval of 6 hours is required between the first and second. GANCICLOVIR SODIUM Side Effects by Likelihood and Severity . COMMON side effects If experienced, these tend to have a Severe expression i . a systemic inflammatory response called sepsis due to an.
Ganciclovir is a cytotoxic antiviral used in the treatment of severe viral infections. During working hours (Monday to Friday), the injection should be reconstituted in the Pharmacy Aseptic Unit (CGH-ext.3033, GRH ext 6515). If treatment is required to commence out of hours contact the on-cal Adult Antimicrobial Dosing, Non-dialysis. These dosing recommendations are meant as guidance based on available literature and should not replace clinical judgement. Antimicrobial dosing should take into account factors specific to the patient (weight, renal function), antimicrobial (pharmacokinetics, pharmacodynamics, toxicity) and disease-state INTRODUCTION. Ganciclovir was the first antiviral agent approved for the treatment of cytomegalovirus (CMV) infection. It is widely used for the treatment of CMV infections among patients with impaired cell-mediated immunity, particularly persons with poorly controlled and advanced HIV/AIDS, and recipients of solid organ and bone marrow transplantation, who are at high risk for invasive CMV. GANCICLOVIR (CYTOVENE) review: Side effects, uses, dosage (injection IV), administration, warnings, precautions, mechanism of action (moa), brand names: Cy..
CYTOVENE IV prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects Ganciclovir Availability. Ganciclovir is an IV medication regularly available from home care services and pharmacies. The oral version of this medication - Valcyte or Valganciclovir - is readily available at most pharmacies. Drug information changes periodically
Guideline: IV Extravasation Management Date of Publishing: 26 September 2016 2:19 PM Date of Printing: Page 7 of 34 K:\CHW P&P\ePolicy\Sept 16\Intravenous (IV) Extravasation - Management.docx This Guideline may be varied, withdrawn or replaced at any time. 3 Risk Factors for Extravasatio Ganciclovir (Systemic) 6/8. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you hav Use of IV ganciclovir or IV foscarnet is reasonable (CIII). The role of oral valganciclovir has not been established. The optimal duration of therapy has not been established. Managing CMV Neurological Disease . Doses are the same as for CMV retinitis. Treatment should be initiated promptly Ganciclovir triphosphate is a competitive inhibitor of herpesviral DNA polymerases, resulting in cessation of DNA chain elongation (Markham and Faulds, 1994). Ganciclovir triphosphate also has some activity against cellular DNA polymerases, and this potential for incorporation into cellular DNA accounts for ganciclovir's significant toxicities
Ganciclovir is an antiviral medicine used to treat CMV retinitis in people with immunosuppression caused by HIV or AIDS. Ganciclovir is also used to prevent CMV disease in people with immunosuppression due to an organ transplant. Ganciclovir may also be used for purposes not listed in this medication guide The phase IV clinical study analyzes which people take Ganciclovir and have Extravasation. It is created by eHealthMe based on reports of 3,779 people who have side effects while taking Ganciclovir from the FDA, and is updated regularly. With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect. Treat initially with ganciclovir 5 mg/kg/dose IV q12hr; once therapy is tolerated, change to valganciclovir 900 mg PO q12hr for 21-42 days or until signs and symptoms have resolved. CMV Prevention in Solid Organ Transplant
Ganciclovir may cause dizziness and visual disturbances. If affected, do not drive or take part in any activity in which you need to be alert. Other side effects may include any of the following: headache, fever, itching of the skin, excessive sweating, vomiting, diarrhoea, nausea, stomach pain, back pain, depression, confusion, and decreased. Ganciclovir by IV Introduction These are instructions for home IV Ganciclovir to clear up CMV (C yto m egalo V irus), an opportunistic infection that often hits people with compromised immune systems, such as transplant patients or AIDS patients.These instructions are conservative. We both pre and post flush and discard the primary tubing and bag each day and the secondary tubing and bag twice. When ganciclovir was administered to lactating rats, ganciclovir was present in milk [see Data]. Advise nursing mothers that breastfeeding is not recommended during treatment with CYTOVENE-IV because of the potential for serious adverse reactions in nursing infants [see Warnings and Precautions (5.1, 5.3, 5.4, 5.5), Nonclinical Toxicology (13.1.
Ganciclovir is an antiviral. It is used to treat infections caused by viruses. Ganciclovir is used to treat the symptoms of cytomegalovirus infection of the eyes in people whose immune system is not working fully.This includes patients with acquired immune deficiency syndrome (AIDS). Ganciclovir will not cure this eye infection, but it may help to keep the symptoms from becoming worse Ganciclovir is a synthetic guanine derivative that is active against CMV and available for IV injection. 30 Selective activity against CMV is conferred by initial phosphorylation to ganciclovir monophosphate by CMV-derived thymidine kinase. Cellular kinases provide the additional phosphorylation steps to generate the active ganciclovir.
Ganciclovir - Disconnecting 7. Disconnect saline syringe by pressing on red lever and pulling apart. 8. Twist off leur lock adaptor from your IV end cap. 9. If heparin is ordered - Use a fresh alcohol wipe to scrub the end cap on your IV line. Scrub for 15 seconds and let air-dry. 10. Twist on the syringe of heparin and flush 11. Throw away. CYTOVENE-IV is the brand name for ganciclovir sodium for injection. CYTOVENE-IV is available as sterile lyophilized powder in strength of 500 mg per vial for intravenous administration only. Each vial of CYTOVENE-IV contains the equivalent of 500 mg ganciclovir as the sodium salt (46 mg sodium) Use of IV ganciclovir w/ oral mycophenolate mofetil may result in increased plasma concentrations of both drugs due to competition for renal tubular secretion. Concomitant use w/ immunosuppressive agents (e.g. azathioprine, ciclosporin, corticosteroids) may result in excessive suppression of bone marrow or the immune system.. Ganciclovir injection comes as a powder to be mixed with liquid and injected intravenously (into a vein). It is usually given every 12 hours. The length of treatment depends on your general health, the type of infection you have, and how well you respond to the medication Ganciclovir - Investigated as a drug, mutagen and tumorigen. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete information. Ganciclovir RTECS Number: MF8407000 Chronic Toxicological Effects: IARC ACGIH OSHA 82410-32- Ganciclovir n.a. n.a. n.a. n.a. 12.1 12.2 12.3.
In animal studies ganciclovir impaired fertility in male and female mice. Based on the occurrence of aspermatogenesis at ganciclovir exposures below therapeutic levels in animal studies, it is considered likely that ganciclovir may cause temporary or permanent inhibition of human spermatogenesis (see section 4.4) Ganciclovir, 9- (1,3-dihydroxy-2-propoxymethyl)guanine or DHPG, is a broadspectrum virustatic agent which inhibits the replication of viruses, including viruses of the herpes group, both in vivo and in vitro: herpes simplex types 1 and 2 (HSV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes zoster (HZV) Valganciclovir, an oral prodrug of ganciclovir, is absorbed and rapidly metabolized to ganciclovir in the intestinal wall and liver . The bioavailability of ganciclovir from valganciclovir is approximately 60%, and the systemic exposure from 900 mg valganciclovir once daily provides similar systemic exposure to that of 5 mg/kg/day i.v.
GANCICLOVIR is an antiviral medicine. It is used to treat or prevent infections caused by certain kinds of viruses. It is commonly used to treat and prevent cytomegalovirus infections of the eye or body Ganciclovir answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web
Maintenance Dosage: Following induction, the recommended maintenance dosage of CYTOVENE-IV is 5 mg/kg (given intravenously at a constant rate over 1 hour) once daily for 7 days per week, or 6 mg/kg once daily for 5 days per week until 100 to 120 days post-transplantation. 2.5 Recommended Dosage in Adult Patients with Renal Impairment . For patients with impairment of renal function, refer to. The incidence of spesis for the oral and intravenous ganciclovir patients was 3 and 8.5%, respectively. Infection at the intravenous site occurred in 0 and 9% of patients, respectively. CONCLUSIONS: Oral ganciclovir offers an effective and safe alternative to intravenous ganciclovir in the maintenance therapy of CMV retinitis. PMID: 763997
Treatment Review Cytovene®-IV, Cytovene®-Capsules Demetrius James Porche, DNS, RN, CCRN Treatment Review is intended to inform and update nurses about treatments relevant to HIV/AIDS Chemical Name: Ganciclovir sodium Brand Name: Cytovene®-IV, Cytovene®-Capsules Medication Classification: Antiviral Background Cytomegalovirus (CMV) is ubiquitous in humans throughout the world; it infects. Valganciclovir is a prodrug of ganciclovir which has been developed for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. Oral valganciclovir is rapidly absorbed and hydrolysed to ganciclovir. The oral bioavailability of ganciclovir after oral valganciclovir administration is high Sample type: Serum Test name: Ganciclovir Condition / Indication: Requesters have found these assays to be of value in patients with renal failure and to monitor oral absorption, particularly in patient receiving valganciclovir. Advance warning: Not normally required during our core working hours (Mon - Fri 09:00 - 17:15). Please contact laboratory to discuss the possibility of this assay. CYTOVENE(R) IV (500 mg/vial) SECTION 11: Toxicological information 11.1. Information on toxicological effects Acute toxicity - LD50 > 2'000 mg/kg (oral, mouse) *1 Local effects - skin: non-irritant *1 Carcinogenicity - carcinogenic *1 Reproductive toxicity - teratogenic and embryotoxic *1 - may lower parental fertility *1 Note - dosage (oral): 1'000 mg (adults) * Although 6 weeks of intravenous (IV) weeks of ganciclovir has been shown to improve long-term hearing outcomes in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the.
ganciclovir and MMF toxicity. (7) •Other drugs associated with myelosuppression or nephrotoxicity:Due to potential for increased toxicity, consider for concomitant use with valganciclovir only if the potential benefits are judged to outweigh the risks. (7) •Didanosine: Ganciclovir coadministered with didanosine may increase didanosine levels The phase IV clinical study analyzes which people take Ganciclovir and have Injection site extravasation. It is created by eHealthMe based on reports of 3,779 people who have side effects while taking Ganciclovir from the FDA, and is updated regularly. With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical. Ganciclovir for Injection, USP is therapeutically equivalent to the reference-listed drug Cytovene (R)-IV, which is marketed by Roche Laboratories, Inc. APP will soon launch Ganciclovir for Injection and will package the product in single dose, 500 mg vials. APP's Ganciclovir for Injection is AP-rated, latex-free and bar-coded Ganciclovir IV. Antimicrobial Companion. Toolkits National Template NHS Ayrshire & Arran NHS Borders NHS Dumfries & Galloway NHS Fife NHS Forth Valley Golden Jubilee NHS Grampian & Orkney. Indication. ZIRGAN ® (ganciclovir ophthalmic gel) 0.15% is a topical ophthalmic antiviral that is indicated for the treatment of acute herpetic keratitis (dendritic ulcers).. Important Safety Information. ZIRGAN is indicated for topical ophthalmic use only. Patients should not wear contact lenses if they have signs or symptoms of herpetic keratitis or during the course of therapy with ZIRGAN The IV ganciclovir dosage was increased from 5 to 7.5 mg/kg every 12 hours to optimize therapy. On this ganciclovir dose, her CMV DNAemia level reached a nadir of 707 IU/mL (log 2.8 IU/mL) by day 75. Despite achieving this viremic nadir, we found evidence in the patient of worsening GvHD refractory to an 8-week course of methylprednisolone (1.